Friday, October 29, 2010

Why HCG injections??

This cycle I've been doing 2000iu injections of HCG on P+3, P+5, P+7, and P+9.  This is not how the average MD uses this.  When I was seeing my RE, I did Ovidrel (brandname HCG) 10,000iu to induce ovulation.  Nobody has really asked me why I'm doing the injections this way, but I thought I would clarify here anyways!

Progesterone and HCG (Human Chorionic Gonadotropin) are naturally occuring hormones with positive effects on the luteal phase of the cycle. The luteal phase is the day after ovulation to the day before the menstrual flow. It is also known as the secretory phase because the progesterone will cause some more thickening of the endometrium as well as vascularization of the endometrium in case of a pregnancy.


Progesterone does not require the presence of a corpus luteum, the residual of the follicle which produces progesterone. Vaginal progesterone gives higher endometrum levels of progesterone and has a moderate effect on the length of the luteal phase. However, sometimes this approach doesn't work because there are different types of luteal phase defects. For instance, sometimes someone needs more estrogen in the luteal phase as well. This is where HCG comes in handy.


HCG increases post-peak or luteal phase progesterone AND estradiol and prolongs the post-peak or luteal phase. HCG is very similar to LH (lutenizing hormone) and one of its main functions is to stimulate the corpus luteum to continue producing progesterone and estrogen. Thus, HCG sustains the functional life of the corpus luteum.
 
I had my P+7 blood drawn and spun on Wednesday, and I shipped it down to the National Hormone Lab at PPVI (saved me 10 bucks to ship myself, woohoo!).  I called today to see if they got it and they did.  Unfortunately I didn't receive a call with the results and don't think I will during the weekend.  So, I have to wait to see if my progesterone and E2 are better than last cycle.  Oh well!

2 comments:

Kakunaa said...

I had to do HCG injections as part of my stims protocol, so it doesn't seem weird to me, LOL.

Reghann and Chris said...

sounds like a good plan!!! one step closer :)